Targetome

Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).

KCC2 neuromodulation remodels metabolic and morphofunctional signatures across the neuromuscular axis in mdx mice

Alex D Assis, Iola MF Duarte, Alessandra Sussulini, Alexandre LR Oliveira

DOI: 10.48130/targetome-0026-0041

Design and delivery of targeting chimeras therapeutics in managing central nervous system disorders

Shuo Liu, Wei Xu, Mengxi Wang, Zhen Mao, Jianping Zhou, Xiaochen Gu, Guochen Han, Yang Ding

DOI: 10.48130/targetome-0026-0028

Drug resistance-driven cytokine alterations in the immunosuppressive microenvironment of colorectal cancer

Yingying Shao, Zewen Zhang, Yu Wang, Chunze Zhang, Erwei Liu, Haiyang Yu

DOI: 10.48130/targetome-0025-0012

Receptor-guided proteolysis at the host-gut microbiota interface: insights from the Bacteroides fragilis toxin-claudin-4 axis

Danni Tong, Weiwei Zheng, Frank J. Gonzalez, Yuhong Luo

2026, 2(5): e046. DOI: 10.48130/targetome-0026-0046

Targeting PTPN2-mediated dephosphorylation destabilizes c-MYC and suppresses acute myeloid leukemia survival

Wenbin Kuang, Dawei Wang, Mingge Song, Jianing Liu, Jiaxing Li, Wenmu Wang, Anyan Chen, Ya Chen, Jiayu Ding, Liping Wang, Wanjian Gu, Yibei Xiao, Xiao Wang, Peng Yang

2026, 2(5): e053. DOI: 10.48130/targetome-0026-0052

The tumor targetome in CAR-T and TCR-T cell therapy

Shijing Wang, Bin Sun, Sandhya Rai, Xinyi Yang, Sariya Banday, Abdullah Memon, Tyce Kearl, Peiman Hematti, Nirav Shah, Jing Dong, Subramaniam Malarkannan, Siegfried Janz, Anita D'Souza, Binod Dhakal, Joseph Zenga, Fumou Sun

2026, 2(5): e051. DOI: 10.48130/targetome-0026-0050

The neuro-immune-metabolic network in ischemic stroke: mechanisms and therapeutic targeting of brain-peripheral organ crosstalk

Jinmei Li, Jingye Yao, Jinnuo Zhao, Yuanyuan Lai, Wei Zhou, Wen Gao, Yi Li

2026, 2(5): e047. DOI: 10.48130/targetome-0026-0045

Dual cognition-improving mechanisms of huperzine A in vascular dementia mice via neurometabolic regulation

Yangfan Zhang, Zemin Li, Ruizhe Nie, Haoqian Wu, Jiajie Li, Xiaoying Cai, Youying Zhang, Xuan Lin, Ruiqi Duan, Shunyuan Liu, Ping Zhou, Yu Fu, Haiping Hao, Xiao Zheng

2026, 2(5): e043. DOI: 10.48130/targetome-0026-0042

Lipotoxicity in MAFLD/MASH: cellular mechanisms and targetable nodes

Joseph Tawai, Kairan Zhou, Jing Xiong

2026, 2(5): e049. DOI: 10.48130/targetome-0026-0047

Spatiotemporal specificity of H3 receptor signaling: from molecular basis to precise regulation of brain function

Yanrong Zheng, Zhuowen Fang, Zhong Chen

2026, 2(5): e045. DOI: 10.48130/targetome-0026-0044

Chinese Medicine for the treatment of pancreatic cancer by targeting the tumor microenvironment: mechanistic insights and therapeutic potential

Le-Ran Xue, Yu-Lin Wu, Zhi-Xiu Lin, Yan-Fang Xian

2026, 2(5): e050. DOI: 10.48130/targetome-0026-0049

Covalent targeting of IP receptor and PTEN mediates pyrrolizidine alkaloid-induced pulmonary hypertension

Caibin Zhang, Xiaokai Guo, Tianyang Huang, Yujian Fan, Yisheng He