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Molecular characteristics, regulatory mechanisms, and targeted therapeutic strategies of Claudin18.2 in pancreatic cancer
Xiaoying Pan, Xinyuan Cao, Jiaojiao Ni, Jieer Ying
2026, 2(4): e034. DOI: 10.48130/targetome-0026-0033
An AI-integrated pharmacophore and transcriptomic framework for rapid discovery of therapeutic leads for ischemic stroke
Jinran Li, Zheng Zhou, Yongjun Zhao, Sai Liu, Long Chen, Yiting Shi, Haotian Li, Yuan Sun, Tingting Yao, Wei Jiang, Qun Xue, Zheying Zhu, Guangji Wang, Xinuo Li
2026, 2(4): e035. DOI: 10.48130/targetome-0026-0034
A photo-clickable, chain-terminating NAD+ analogue enables systematic profiling of the PAR-interacting proteome under oxidative stress
Lijuan Gao, Zhenlin Tu, Yangyang Zhou, Yanhui Xu, Yueqi Sun, Tianye Dai, Jinbo Zhan, Mengwei Li, Xiao-Nan Zhang
2026, 2(4): e031. DOI: 10.48130/targetome-0026-0030
From molecular markers to architectural control: cytoskeletal checkpoints as the decisive state-access layer of the aging microglial targetome
Inês Mendes Pinto, Pedro Beça, Miguel Correia, Joana T. Moreira, João Galvão, Camila C. Portugal, João B. Relvas, Renato Socodato
2026, 2(4): e038. DOI: 10.48130/targetome-0026-0035
Drugging the efferocytosis process for treating hepatic fibrosis: dual roles, mechanisms, and therapeutics
Yaning Chen, Yingyin Sun, Xin Chen, Yuchen Liu, Hua Wang
2026, 2(4): e032. DOI: 10.48130/targetome-0026-0031
Nesprin-2-mediated epigenetic remodeling under mechanical load: anti-tumor mechanisms and strategies
Fangfang Liu, Jinjian Lu
2026, 2(4): e033. DOI: 10.48130/targetome-0026-0032
Molecular pharmacotargets in donor cardiac graft preservation: mechanisms and translational perspectives
Chenchen Sun, Xiangwang Zhao, Jiangyang Chi, Yonghui Zhang, Zhengxi Hu
2026, 2(4): e036. DOI: 10.48130/targetome-0026-0039
From target fishing to AI and single-cell multi-omics: an integrated framework for natural product target research
Haojie Du, Nana Chen, Yang Sun
2026, 2(4): e037. DOI: 10.48130/targetome-0026-0036